منابع مشابه
Regnase-1 and Roquin regulate inflammatory mRNAs
Inflammation is mediated by proinflammatory cytokines such as tumor necrosis factor (TNF) and interleukin 6 (IL-6). Innate immune cells sense pathogen infection via Toll-like receptors (TLRs) and rapidly induced production of cytokines. The expression of cytokine genes is tightly regulated at both transcriptional and post-transcriptional levels. Whereas transcription is the first step in the re...
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Zc3h12a is a lipopolysaccharide-inducible gene and has a CCCH-type zinc-finger domain. Zc3h12a knockout mice develop spontaneous autoimmune diseases accompanied by splenomegaly and by lymphadenopathy. Subsequent studies show that Zc3h12a is a nuclease involved in destabilization of interleukin (IL)-6 and IL-12 mRNA via the stem loop structure within the 3' UTR of these genes. Thus, we renamed i...
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Extracellular high mobility group box 1 (HMGB1) has been demonstrated to function as a proinflammatory cytokine and induces neuronal injury in response to various pathological stimuli in central nervous system (CNS). However, the regulatory factor involved in HMGB1-mediated inflammatory signaling is largely unclear. Regulatory RNase 1 (Regnase-1) is a potent anti-inflammation enzyme that can de...
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One of the assumptions of the AME bioassay is false. However, the . assumptions underlying the TME bioassay appear to be valid providing the excre,ta energy values of all birds are adjusted to zero nitrogen balance. The adjustment controls variation in metabolic plus endogenous energy loss-associated with the physiological state of the bird, the environment in which it lives, and the nature and...
متن کاملRegnase-1 and Roquin Regulate a Common Element in Inflammatory mRNAs by Spatiotemporally Distinct Mechanisms
Regnase-1 and Roquin are RNA binding proteins essential for degradation of inflammation-related mRNAs and maintenance of immune homeostasis. However, their mechanistic relationship has yet to be clarified. Here, we show that, although Regnase-1 and Roquin regulate an overlapping set of mRNAs via a common stem-loop structure, they function in distinct subcellular locations: ribosome/endoplasmic ...
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ژورنال
عنوان ژورنال: Nature Immunology
سال: 2020
ISSN: 1529-2908,1529-2916
DOI: 10.1038/s41590-020-0591-y